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A Gnotobiotic Mouse Model Demonstrates that Dietary Fiber Protects Against Colorectal Tumorigenesis in a Microbiota- and Butyrate–Dependent Manner

Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.

Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre.

G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer.


Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women


Inulin-Type Fructans: Functional Food Ingredients


Guar gum as a promising starting material for diverse applications: A review.

Microbiota benefits after inulin and partially hydrolized guar gum supplementation: a randomized clinical trial in constipated women.

Partially Hydrolyzed Guar Gum in the Treatment of Irritable Bowel Syndrome with Constipation: Effects of Gender, Age, and Body Mass Index

Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro

Butyrate: A Double-Edged Sword for Health?

Maternal butyrate supplementation induces insulin resistance associated with enhanced intramuscular fat deposition in the offspring.

Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice.


~Because…Too many tabs…8-)

WORMBOOK <—Awesome Sause

Wormbook-History Page

A Collection of Conditions Transmitted by Insects or Ticks

The biology of Strongyloides spp. from WormBook: The Online Review of C. elegans Biology [Internet].

Strongyloides stercoralis: a model for translational research on parasitic nematode biology

Host-finding behavior of Strongy

Copper – Cu Toxicity

Strongyloidiasis Hyperinfection in a Patient with a History of Systemic Lupus Erythematosus

Circulating Non-Human Microfilaria in a Patient with Systemic Lupus ErythematosusSee Below

A 12-yr-old girl with systemic lupus erythematosus requiring steroid therapy was found to have a circulating microfilaria during an exacerbation of her illness. Morphologically, the microfilaria does not correspond precisely with any previously described species, though similarities exist between the patient’s microfilaria and those of Dipetalonema reconditum of the dog and D. interstitium of the grey squirrel. The organism reported here is probably an undescribed species from a wild mammal. Although the association may be merely coincidental, this case suggests that compromised immunity might have led to this unusual infection with a non-human filaria.

Copyright © 1978 by The American Society of Tropical Medicine and Hygiene

Sporotrichosis, terbinafine and potassium iodide.

Sporotrichosis successfully treated with terbinafine and potassium iodide: case report and review of the literature.

Sporotrichosis is rare in Turkey. We report a 40-year-old woman who had subcutaneous sporotrichosis caused by sporothrix schenckii that was successfully treated with terbinafine (250 mg, twice a day) for a period of 6 months. She received a saturated solution of potassium iodide orally for two months. Terbinafine and potassium iodide are suggested to be the agents of choice for treatment of subcutaneous sporotrichosis.

Successful treatment of terbinafine in a case of sporotrichosis.

Sporotrichosis is a chronic subacute infection caused by fungi belonging to the Sporothrix Complex. In the present clinical case, nasal sporotrichosis was treated with potassium iodide. This was unsuccessful, and the treatment was restarted with a combination of potassium iodide and itraconazole. This however resulted in a further recurrence of the infection. The mycological cultures were tested in vitro for antifungal activity to assist in treatment. Terbinafine, an antifungal drug, produced the best results and was therefore used for the rest of the treatment course, with no recurrence after two years of its completion. In addition, both cultures were compared using RAPD and different fragment patterns were observed. This indicated that the isolates were either different or indicated a microevolutionary process of this microorganism.

C.T.C.L. Diaries – Terbinafine

Be cancer’s antimatter.

NIH – Mycosis on mycosis fungoides: zoophilic dermatophytosis selectively superimposed on pre-existing cutaneous T-cell lymphoma (mycosis fungoides) plaques.

Antifungal Agents


An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Polyene Antifungal Drugs

Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside.

Azole Antifungal Drugs

Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function.

Allylamine and Morpholine Antifungal Drugs

Allylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step.

Antimetabolite Antifungal Drugs

5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Selection of Antifungal Agents

In vitro susceptibility testing with the fungi is not yet standardized, and the results of in vitro tests do not always compare to the results obtained in vivo. Therefore, preliminary selection of an antifungal agent for clinical use is made primarily on the basis of the specific fungal pathogen involved. The spectrum of activity for the licensed antifungal agents is well defined through the results of preclinical and clinical testing with the most common fungal pathogens. This approach is useful in avoiding selection of antifungals for species of fungi that are known to have primary resistance to the agent, but less useful in selecting antifungals for species that are known to develop secondary (drug induced) resistance to a particular agent.

Antifungal drug resistance has become an increasing problem with the development of a larger compendium of antifungal agents. Drug resistance to the polyene antifungals is almost always primary resistance rather than secondary resistance. That is, the susceptibility profiles for the species are characteristic and inherent, and rarely change in response to exposure to the agent. For example, amphotericin B-resistant species such as Pseudallescheria boydii and Candida lusitaniae are well known, and do not appear to have originated from exposure to the antifungal. Despite decades of widespread clinical use of amphotericin B in Candida albicansinfections, the development of secondary resistance has been exceedingly rare. In contrast, both primary and secondary resistance to 5-fluorocytosine are known to occur for strains of Candida species, serving as the basis for restricting use of this agent to combination therapy with other antifungal drugs.

The question of fungal resistance to the azole drugs is considerably more complex and is currently under evaluation. Examples of both primary and secondary resistance are known for the medically important yeasts and selected azole antifungals. Candida krusei as a species is typically resistant to fluconazole. Candida albicansstrains are typically susceptible to fluconazole and certain other azole antifungals, but there are increasing reports of resistance, especially in HIV-infected hosts having undergone repeated courses of azole antifungal therapy. The question of drug resistance is complicated by the limitations in the available susceptibility testing methodology and the ability to distinguish between microbiological and clinical drug resistance. The latter typically occurs when an inhibitory antifungal agent reaches the limits of its activity in a host with a decreasingly efficient immune system.

With the advent of the polyenes, azoles, and fluorocytosine, previously fatal infections can now be treated. However, as modern medicine continues to extend life through aggressive therapy of other life-threatening diseases such as cancer, there is an increasing population at risk for opportunistic fungal infections. Such patients represent a special challenge because they often are left with little host immune function. Therefore, chemotherapeutic agents should be fungicidal and not just fungistatic. The search continues for fungicidal agents that are nontoxic to the host. Research is also directed toward immunomodulating agents that can reverse the defects of native host immunity.

Outline of the Organon

~Content Source

This outline was prepared by Julian Winston for the students of the Wellington College of Homeopathy. It was printed in the USA in Homeopathy Today.

It was taken from the 5th edition, translated by Dudgeon (1893), with additions (where needed) by Boericke (1922) from the 6th edition, and cross referenced with the Kunzli translation of the 6th.

When substantial changes were made between the 5th edition of 1833 and the 6th edition of 1842, the 5th will be in italic type and the 6th will be in plain type.

An asterisk ( *) indicates a footnote well worth reading.

Paragraph 1-9: Basic postulates about disease and what Healing is about.

1. The physician’s only mission is to cure the sick; it is not to speculate on the nature of disease.*
2. The ideal cure is rapid, gentle, permanent and removes the whole disease in the shortest, least harmful way, according to easily comprehensible principles.
3. If the physician understands what is curable in disease, and understands what is curative in medicines, and understands how to apply the medicines (according to well defined principles) to the disease, and knows how to remove conditions which prevent the patient from getting well, he is a true physician.
4. The need to recognize and remove the maintaining causes
5. Pay attention to the exciting cause AND the fundamental cause (which is usually a chronic disease) including the patient’s character, activities, way of life, habits, etc.
6. There is no need for metaphysical speculation. Diseases are the totality of the perceptible symptoms *
7. To cure, you only need to treat the totality [NOT symptomatic palliation; a single symptom is not the disease] *
8. If the symptoms are removed, the disease is eradicated
9. The physician want to make people healthy so they can use their body to get on with the higher purposes of their existence.

10-18: The concept of vital force and its relation to disease

10. Without the vital spirit (force), the organism is dead
11. In diseases, it is the vital force that is deranged. *
12. The vital force produces the disease THEREFORE if the vital force is cured, the disease is cured. [how it does so is of no concern to the physician]
13. Diseases are not peculiar or distinct entities. It is absurd to think so. Only materialistic minds think so. It is this thinking that has pushed conventional medicine along, making it mischievous (an art of darkness), incapable of healing.
14. Everything morbid is curable
15. The diseased vital force and the symptoms of the disease are the same
16. Since diseases are, therefore, spirit-like, you need spirit-like medicines to be effective against them.
17. The physician only needs to eliminate the totality of symptoms, which will remove the inner alteration
18. The TOTALITY is the only guide to the remedy

19-21: The need for provings (determine the nature of medicine)

19. Medicines cannot cure unless they can cause derangement
20. The power of medicines can be discovered only by their effects– not by reason.
21. Symptoms of provings are the only way of learning their power. Pure experiment will reveal nothing. Remedies cure only because of their ability to alter human health by causing characteristic symptoms.

22-27: The principle of similars

22. The curative powers of medicines exist only because they can produce symptoms in the healthy and remove them from the sick. Medicines can be similar or opposite to the disease. Which to use is revealed by experience. [description of allopathic medicine]
23. But experience shows that anti-pathic drugs don’t cure; the symptoms return with renewed intensity
24. Therefore homeopathy is the system of choice.
25. This can be learned by pure experiment [not the kind of experiment which is conducted by the regular physician, which is like looking into a kaleidoscope] *
26. A weaker dynamic affliction is extinguished by a stronger IF it is similar in nature.
27. Curative powers depend upon the symptoms they produce being similar to the symptoms of the disease, but stronger.

28- 29: HOW IT WORKS (attempt) rewritten in the 6th.

28. Scientific explanations of how it works are of little importance, there is no value in attempting one. Nevertheless…
29. The artificial disease of the remedy overpowers the weaker natural disease. When the force of the artificial disease is spent, the body returns to normal health. This is a most probable explanation.

30-69: Lays out the philosophy of the system

30. The human body is more disposed to let it’s state of health be altered by drugs than by nature.
31. Disease agents do not affect everyone. We fall ill only when susceptible. [SUSCEPTIBILITY]
32. Medicinal agents can affect all people.
33. The body is, therefore, more susceptible to medicinal forces.
34. The artificial disease does not only have to be stronger, but it has to be most similar. [the vital principle is instinctive, unreasoning, and without memory]. Nature cannot cure an old disease by adding a new dissimilar one.
35. Consider when two dissimilar diseases meet in the same person [examples are given in paragraphs 36-40]
36. Old diseases keep away new dissimilar diseases.
37. Chronic diseases are not affected by non-homeopathic treatment.
38. New, stronger diseases can suppress old disease but will never remove it
39. Allopathic treatment suppresses the disease, then the chronic disease returns when the medication is withdrawn.
40. New diseases can join older diseases and become complex. Neither removes the other
41. Heavy drugging with allopathic medicines leads to an artificial drug disease and makes it into a chronic problem
42. Two dissimilar diseases can exist in the body at the same time
43. But when two similar diseases meet we can observe how cure takes place.
44. Two similar diseases cannot suspend, ward off, or exist at the same time.
45. Two similar diseases will destroy each other in the organism.
46. Examples of the above.
47. It should be convincingly clear that this is how to cure according to natural law.
48. Dissimilar diseases don’t cure.
49. Nature is poor in remedial homeopathic diseases, so we do not notice them often.
50. And those that can cure, bring other problems, often because the dose cannot be controlled.
51. But the physician has many medicines available

52-56 have been totally re-written in the 6th edition

52. By looking at nature, the physician will learn to treat only by homeopathy.
52. there are two methods: allopathic and homeopathic. Each opposes the other. To practice both at the whim of the patient, is criminal

53. Mild cures can happen ONLY through homeopathy. It should be the first mode of employing medicines
53. True, gentle cures, can only be homeopathic

54. The homeopathic way is the only one.
54. allopathic practice is based on conjecture

55. the 2nd mode is allopathic
55. the only reason people stuck by allopathy is that it afforded palliative relief

56. the 3rd mode is anti-pathic or palliative
56. Patients were deceived by quick improvement, but this method is fundamentally harmful.

57. Examples of treating a single symptom with a contrary remedy
58. Why anti-pathic is bad. Directed against a single symptom: a short amelioration followed by a long aggravation
59. Examples of injurious effect of anti-pathic medicine
60. Increasing doses of a palliative medicine never cures
61. Physicians (if they had been capable of reflecting upon the sad results) should see the result of applying contrary medicines and understand that the homeopathic way is better and the only way to cure
62. The reason palliation is dangerous is explained in paragraphs 63-69.
63. The primary action of the medicine and the secondary reaction of the vital force or counter reaction).
64 Explanation of primary and secondary reactions.
65. Examples of primary and secondary effects as stated in paragraph 64.
66 In a healthy body, one does not notice the secondary reaction to homeopathic doses, but the primary action of some of these remedies is perceptible to a good observer.
67. These TRUTHS explain why homeopathy is good. [long footnote condemning those of the “mongrel sect” who claim to be homoeopaths but use palliation to avoid looking for the correct remedy] *
68. In homeopathy, experience shows that a small dose of medicine will extinguish the natural disease.
69. Exactly the opposite happens in anti-pathic treatment. The disease becomes worse when the palliation wears off.

70: Summary of all that has been said so far

71. All diseases are groups of symptoms that can be cured by similar remedies. There are three points for curing: investigate the disease, investigate the remedies, learn how to employ them. (see Para. 3)

72-81: Acute and Chronic diseases

72. Diseases–definition of acute and chronic
73. Discussion of acute disease
74. The worst Chronic diseases are produced by unskilled physicians using allopathic medicines
75. These diseases are the most incurable.
76. Homeopathy can cure natural diseases. The debilitations of allopathic care can only be removed over time by the vital force itself (with treatment of any miasm that is in the background).
77. Some diseases are called “chronic” but are not– addictions and indispositions. Remove the cause and remove the disease
78. Real chronic diseases arise from the chronic miasms
79. Syphilis and sycosis
80-81. psora (read Chronic Diseases, published in 1828)

82-104: CASETAKING (how to elicit the information)

82. In trying to cure these diseases, the case is to be conducted carefully
83. Requisites for understanding the picture of the disease: Freedom from prejudice and sound sense. The individualizing examination of a case of disease (general directions)
84. Patient talks. Physician keeps quiet. Do not interrupt. Write it all down.
85. Start a new line for every symptom
86. When patient finishes, ask for particulars
87. Don’t ask “yes” or “no” questions
88. Ask about other parts of he body not mentioned
89. The physician should then ask more special detailed questions
90. The physician notes what he observes in the patient
91. In chronic cases, understand what the symptoms are before the medicines were taken. Ask to discontinue to see the real disease.
92. In diseases of rapid course (acute) forget the other medicines. Do what you can to sort it out
93. See what the friends say about the patient
94. In cases of Chronic Disease, ask about habits, diet, and domestic situation to be able to remove the maintaining causes
95. In cases of Chronic Disease, the most minute peculiarities are attended to
96. Some patients might exaggerate their symptoms
97. Others have false modesty and allege that their symptoms are of no consequence
98. Attach credence to the patient’s own expressions
99. Acute diseases are of short duration and easy to treat. There is less to inquire into and are often spontaneously detailed

100-102: epidemic diseases

100. Investigating epidemic diseases.
101. It takes time to see the totality of the epidemic disease
102. You see the characteristics of the disease through several patients

103- 104 : chronic diseases

103. Chronic disease must be carefully investigated. You must see the totality of the patient.
104. Once the totality is sketched, the most difficult part is done. The physician has a picture of the disease. To see the effect of the medicine, just ask how the patient is, and cross out the symptoms that have been cured

105- 120: The effects of the remedies

105. The second point is to know the remedies
106. The pathological effects of several medicines must be known, so we can select among them
107. You can’t learn much about the effects of medicines by giving them to sick people, because the symptoms of the medicine will be mixed up with the symptoms of the natural disease
108. You must do provings to find out the medicinal effects
109. I was the first to suggest this method
110. All those who have seen the effect of poisons could have never understood that the morbid lesions were simply the clues to the curative powers of the drugs. It can’t be learned by a priori speculation, nor by the senses.
111. I have observed pure effects of the medicines– without any reference to therapeutic object– and they produce certain, reliable disease symptoms, each according to its own peculiar character.
112. Dangerous effects are seen at the termination of symptoms when given in large doses. This recalls the primary actions (Para. 63) and secondary action (Para. 62-7). The human organism reacts as much as is needed to raise the health to a normal healthy state.
113. The only exception is narcotic medicines, where the secondary action produces greater irritation and sensitivity.
114. With the exception of the narcotics, we observe the primary action when given in moderate doses to healthy people
115. Certain symptoms which are opposite are not secondary but, rather, alternating actions
116. Some symptoms are produced frequently, and others rarely or in few persons
117. The rarely produced symptoms are idiosyncrasies– the substances produce seemingly no impression in others. But when used homeopathically they can heal ALL individuals
118. Every medicine has a unique action
119. Each substance cannot be confused with another
120. Therefore, all medicines must be carefully distinguished from each other, so the physician can choose the correct remedy.

121-142: Conducting provings

121. Strong substances produce effects in small doses, weak substances produce effects in larger doses, and the mildest must be tested on very sensitive people
122. The medicines used in provings must be pure and well known
123. They must be taken in a pure form
124. They should not be mixed with other substances
125. The diet of the provers should be strictly regulated and simple. No stimulating drinks. [footnote giving specific restrictions]
126. The prover must be trustworthy and devote himself to observation. He must be in good health and intelligent enough to be able to describe sensations accurately
127. The provings should be done by both sexes
128. Provers should take 4-6 globules of the 30th daily for several days
129. If effects are slight, then take a few more globules. Start with a small dose and increase daily
130. If the first dose produces symptoms, then the experimenter can learn the order of succession of the symptoms– which is useful to learn the primary and alternating actions. The duration of action can be found only after a comparison of several experiments
131. If you have to give the medicine for several days, you can’t learn about the order of symptoms. One dose might act curatively of symptoms caused by the previous dose. Record these symptoms in brackets until further experiments show if they are secondary action or alternating action.
132. But if you are just interested in symptoms and not in the order, give it every day.
133. You must learn the exact character of the symptoms–the modalities are most important
134. Not all symptoms will be seen in one person
135. The whole picture of the remedy can be understood through a study of all the provings. The substance is thoroughly proved when no new symptoms are seen
136. Although only certain people are susceptible to remedies when healthy, ALL people are susceptible to the simillimum when sick
137. With mild doses in sensitive people, the primary effects can be observed. But excessively large doses will lead to a mixture of primary and secondary effects in “hurried confusion.”
138. All symptoms during a proving are symptoms of the medicine even though the prover may have experienced them before
139. The prover must note all details and the physician should question the exact circumstances
140. If the person can’t write, he should talk to the physician every day
141. The best provings are done by the physician upon himself. Experience shows that continued provings lead to robust health.
142. In practice, judgement is always needed to separate the symptoms of the remedy from the symptoms of the malady

143- 145: The formation of the materia medica

143. If we collect all the symptoms produced, we have a true materia medica
144. Nothing conjectural, imaginary, or mere assertion should be included in the book
145. If the symptoms are accurately stated, we now have a curative substance for every disease

146-171: The application of the medicine to the disease

146. The third point concerns the use of the medicines. The physician must be judicious in his use of these agents
147. The most similar must be used

[the following two paragraphs were re-written in the 6th edition; although the explanation changes, the content is the same]
148. An explanation of how homeopathy probably works.
149. Acute diseases can respond quickly, but chronic diseases take longer to treat.

150. trivial symptoms of short duration are indispositions and can be cured by diet and regimen
151. More violent sufferings will provide, upon investigation, a complete picture of the disease
152. The numerous striking symptoms will lead to a homeopathic remedy
153. The striking, singular, uncommon, and peculiar signs and symptoms are the most important. The general symptoms are observed in every disease and from almost every drug
154. If the striking symptoms of the medicine match those of the disease, and the disease is not one of long standing, it will be removed by the first dose, without “considerable disturbance.”
155. The other symptoms of the disease (“which are very numerous”) are not part of the case and are not “called into play.”
156. If the patients are very sensitive they MIGHT produce a “trifling” new symptom. (it is impossible that the disease and the remedy cover each other like identical triangles) but this symptom is not perceptible in patients not “excessively delicate.”
157. But in certain cases [6th ed. when the dose is not sufficiently small .], there might be an aggravation for the first hour or so. This is nothing but the medicinal disease exceeding the strength of the original disease.
158. This “aggravation” is a sign that the remedy was correctly chosen.
159. The smaller the dose [6th ed. in the treatment of acute diseases ] the less the aggravation
160. The dose can’t ever be made small enough to not relieve, so any dose, if not the smallest possible, will produce an aggravation
161. During chronic treatment, there may also be an aggravation, but not as immediate [6th ed. in chronic diseases where the smallest dose is dynamized between doses (LM) aggravations appear at the end when the cure is almost quite finished ]
162. Since we don’t know ALL medicines, we often have to give the one which is closest.
163. If we do, we can’t expect a complete cure. We might see new symptoms which are not part of the disease, but of the medicine.
164. A small number of symptoms is no obstacle to cure IF the symptoms are peculiarly distinctive (characteristic)
165. If you prescribe on non-characteristic symptoms, and can find no remedy more appropriate, the physician cannot “promise himself any immediately favorable result.”
166. These cases are rare, since we know more and more remedies. When they do happen, the selection of a subsequent, more accurate remedy is needed
167. So in acute diseases, if the wrong remedy is given, and you see new symptoms in the case, give the correct (new) remedy now seen.
168. Give the best remedy, re-study the case, give the best remedy. [zig-zag] (because we don’t know all the remedies)
169. If two remedies are close, give the closest one. Do not give the other without re-examining the case– because the case may change and there might be a more appropriate selection. [6th ed. never give two remedies together ]
170. When re-examining a case, if the next best remedy is clearly indicated, give it.
171. In non-venereal diseases (psora) we often need several remedies to cure– each chosen [after the completion of the action of the previous remedy] and selected on the symptoms remaining.

172-184: one sided cases

172. A similar difficulty occurs when there are too few symptoms. These cases deserve our careful attention
173. There are certain chronic diseases that have few symptoms. These are “one sided” cases.
174. The complaint may be internal or external (local maladies)
175. In the first kind it might just be the lack of discernment on the part of the practitioner
176. Still, there might be just one or two symptoms after a well taken case
177. In these VERY RARE cases, we should give the remedy that is homeopathically indicated
178. Sometimes, this will cure the case– especially if the symptoms are characteristic
179. More frequently, the medicine will cover the case only partially
180. This leads to a new array of symptoms, some of the disease itself, which have never before been noticed
181. These new symptoms, while they might owe their origin to the remedy, are the symptoms of the disease– and we should direct further treatments accordingly.
182. The imperfect selection of the remedy, in these cases, opens the case to the discovery of the more accurate remedy.
183. When the first dose ceases action, the second remedy can be selected.
184. Keep taking the case after each new remedy until recovery is complete.

185-203: local diseases

185. Local maladies appear on external parts of the body. That they stand alone is absurd.
186. Problems which are “local” and have been produced from without have great effect on the whole living organism. When mechanical aid is needed, then surgery is required (setting bones, bringing skin together, extracting foreign objects, etc.) but the whole living organism requires dynamic aid to accomplish the work of healing.
187. But “local” manifestations that are not produced by external injury have their source within the body. To see them and treat them as external is as absurd as it is pernicious.
188. It is absurd to think that living organisms know nothing of these external problems.
189. All external maladies (except injuries) come about as a result of an internal diseased state.
190. All treatments, therefore, must be directed against the whole.
191. This is confirmed through experience.
192. All changes, not just the local affliction, must be taken into account when determining the remedy.
193. When the dose is taken, the general morbid state of the body is cured, and with it, the local affliction– which was an inseparable part of the whole disease.
194. In local diseases it is of no use to apply remedies locally for the topical affliction, even if it is the same remedy that is used internally. If the vital force was not competent to restore full health, then the acute disease was a manifestation of latent psora which has now burst forth.
195. To cure such cases (which are not rare), give the anti-psoric remedy after the acute stage has subsided. This is all that is required in non-venereal cases.
196. It might seem that cure would be hastened by the application of the remedy locally as well as internally.
197. This should not be done. In diseases where there is a local affliction, the application of the remedy to the surface may annihilate the local symptoms before the internal disease, and this may seem to be a cure but isn’t.
198. The use of topical applications alone is inadmissible. If you only remove the local symptoms, it is often hard to see the more obscure inner symptoms (which may be slightly characteristic and difficult to see)
199. If the external symptoms have been removed (by surgery, etc.) the remaining internal symptoms might be too vague to discover the remedy because the external symptoms can no longer be seen.
200. If it hadn’t been removed, the remedy of the whole disease would have been found and would have resulted in a perfect cure.
201. The vital force, when expressing a chronic disease keeps the disease on the surface, and therefore not threaten life itself. But since the external manifestation is a part of the general disease, as the disease gets worse the external manifestation gets worse– so it can still be a substitute.
202. If the external disease is now destroyed, nature will make up the loss by increasing the internal disease. This is incorrectly referred to as being “driven back into the system.”
203. Removing the external without treating the internal is a criminal procedure.

204-209: Introduction to the treatment of chronic disease

204. If we exclude all chronic diseases that are caused by unhealthy living (Para. 77) and all medicinal diseases (Para. 74), most of the remainder of chronic diseases, WITHOUT EXCEPTION, are caused by the three miasms, sycosis, syphilis, and a greater proportion, psora.
205. The homoeopath will never treat the primary symptoms, but only cures the underlying miasm. Refer to Chronic Diseases.
206. When taking the chronic case, make a careful investigation if the patient ever had venereal disease. Two miasms might be present, but, frequently, psora is the sole fundamental cause of all chronic disease.
207. Find out what kind of allopathic treatment had been had, to understand how the disease has changed
208. The patients age, mode of living and diet, occupation, domestic position, social relation, etc. must be taken into consideration, as well as the state of the mind and the disposition.
209. Trace the picture of the disease, and get the patient to tell the most striking and peculiar symptoms.

210-230: mental diseases

210. All one-sided diseases are psoric. Mental diseases are not a separate class, since in all diseases the mind is altered
211. The disposition of the patient often determines the selection of the remedy– because they are often characteristic symptoms which “can least of all remain concealed from the accurately observing physician.”
212. The Creator of healing forces also thinks highly of this as all medicines (which he created) affect the mind
213. We can’t cure diseases if we do not observe the disposition and the state of mind.
214. Mental diseases are to be cured the same was as all other diseases
215. All mental diseases are physical ones, where the physical symptoms are so slight as to make the disease seem to be one-sided
216. Many physical ailments of an acute character, transform into insanity whereupon the physical symptoms cease.
217. In such cases we must look to the whole phenomenon– the physical and mental
218. The symptoms include previous physical symptoms– which may be learned from friends or relations
219. Those symptoms will be found to be still present, though obscured
220. The complete picture of the disease can then be prescribed upon– usually an anti-psoric remedy
221. When insanity comes on acutely after a fright, etc., it should not be treated with anti-psorics (although it arises from an inner psoric state bursting forth), but with the other class of proved remedies (Aconite, Belladonna, Stramonium, etc.) until the patient returns to his latent state.
222. But such patients are not cured. They should be “freed completely” by anti-psoric treatment.
223. If this is not done, the patient will have recurring attacks, each brought on by a slighter cause.
224. If it is not certain that the mental disease arose from physical illness rather than from “faults in education, bad practices, corrupt morals, superstition or ignorance”, see if it can be improved by “friendly exhortations, consolatory arguments, serious representations, and sensible advice.” Real disease will be speedily aggravated by such a course.
225. There are some emotional illnesses that will, if left alone, destroy the physical health.
226. These may be treated, in an early stage, by “displays of confidence, friendly exhortations, sensible advice, and often by well-disguised deception.”
227. But the underlying cause is a psoric miasm (which is not fully developed) and must be treated.
228. With mental diseases that come from physical maladies, we must also treat the patient well and “not reproach him for his acts” or use punishment or torture. The only reason coercion is justified is the giving of the remedy– but it could be given in a drink without the patient’s knowledge.
229. The physician and the keeper must always pretend to believe them to be possessed of reason
230. If anti-psorics are used than the case can be cured [confidently assert]

231-244: intermittent diseases

231. Intermittent diseases are those that recur at certain periods and states which alternate at intervals
232. Alternating diseases are numerous and belong to the class of chronic disease. They are, generally, a manifestation of chronic psora. Read Chronic Diseases.
233. In the typical intermittent disease, the same state returns at fixed periods
234. The non-febrile intermittent diseases are, mostly, purely psoric and seldom complicated with syphilis, but sometimes they need a small dose of Cinchona to completely extinguish them.
235. In intermittent fevers, when the symptoms alternate, the remedy should produce similar alterations.
236. The best time to give the medicine is soon after the paroxysm
237. But if the state of no fever is short, give the remedy when perspiration begins to abate
238. The remedy can be repeated if the symptoms return and have the same picture. If the fever is brought on by marshy districts, then permanent restoration can only be had by getting away from the causative factors.
239. All fevers may be cured with homeopathic remedies
240. If cure is not possible, it must always be because of the psoric miasm, which must be treated
241. Epidemics of intermittent fevers are of the nature of chronic diseases. Each epidemic is of a uniform character which will reveal the common totality– which will lead to the (specific) remedy for all cases.
242. If the person is very weakened, then an anti-psoric remedy would be needed, generally a minute and rarely repeated dose of Sulphur or Hepar sulphuricum in a high potency
243. If a single person is attacked, find the totality and give the remedy. If cure is not complete, give an anti-psoric.
244. Persons who can’t be cured by a few doses of cinchona, have psora at the root of the malady, which needs to be treated.

245-263: how to use the remedies

245. We will now talk about how to use remedies and the diet and regimen during their use

Paragraphs. 246-248 are totally re-written in the 6th edition

246. The best selected remedies should be repeated at suitable intervals
246. Don’t repeat as long as there is amelioration (in acute disease). In chronic disease this may also be the case at times. But this is rare. If the medicine is well selected, highly potentized, dissolved in water, and given properly (that the degree of each dose is changed), a cure will result. [footnote describing the new method]

247. Smallest doses may be repeated
247. The remedy must be changed in potency each time it is given

248. The dose may be repeated until action is exhausted
248. How to do it. The instructions for changing the potency each time. Aggravation comes at the end. Even a one dram vial of alcohol with one globule that is used for olfaction must be succussed 8-10 times before each dose.

249. If new and troublesome symptoms are produced by the remedy, it is not homeopathic and should be neutralized and/or the next remedy be given immediately to take the place f the improperly selected one.
250. When you see the wrong remedy is given, find and give the right one!
251. Some medicines have alternating actions. If you give one (Ignatia, Bryonia, Rhus tox) and no improvement follows, give it again
252. If nothing happens after the most suitable remedy is given, there is an obstacle to cure in their mode of life
253. In acute diseases the first positive changes are usually mental– a freedom of mind, higher spirits. The opposite is seen in an aggravation.
254. The observing physician will note these changes while the patient might not
255. If you go through the case point by point and notice no changes in symptoms, but the patient’s disposition is better, the medicine might just need more time to act, there might be an obstacle to cure, or the dose was not small enough
256. If the patient has new symptoms– signs that the medicine was not correct– but says he feels good, we must not believe it.
257. Do not make any remedies “your favorites” because you will neglect many others, perhaps better, remedies.
258. If you avoid some remedies because you have bad results with them (through your own fault), remember that ALL remedies are useable when the similarity to the totality is matched and “no paltry prejudices should interfere with this serious choice.”
259. Because the doses are so small, anything which has medicinal action must be removed from the diet and regimen.
260. In chronic diseases this is even more important (followed by a list of things to avoid)
261. The best thing in chronic diseases is to remove the obstacles to recovery, and encourage recreation, exercise, and good food
262. In acute diseases, the patient should be allowed to eat what he wants
263. The desires are to be granted within moderate bounds, the room and temperature should be controlled as the patient wishes

264-271: the medicines

264. The physician should have pure medicines to use
265. The physician should see that the patient takes the right medicine (6th ed. prepared by the physician himself)
266. Animal and vegetable remedies are most perfect in their raw state
267. Instructions for making extracts
268. With materials that are not supplied fresh, you must be convinced that they are genuine
269. Description of potentization [conceptual]
270. Description of making centesimal potencies (6th ed: LM potencies)
271. Description of trituration (6th ed: the physician should do it himself)

272-279: administering the remedies

272. In no case is it needed to give more than one remedy at a time (6th ed: one globule is OK, but dissolved in water and stirred well will touch many more nerves)
273. How can one not understand that one remedy at a time is the only way (6th ed: It is absolutely not allowed in homeopathy to give the patient at one time two different remedies)
274. Single remedies are proven and have totalities. If you give two you can’t evaluate the results
275. You must control the size of the dose as well
276. Even if the remedy is homeopathic it can do harm in too large a dose and more harm the higher the potency. “Too large doses too frequently repeated bring trouble.”
277. If the dose is sufficiently small it will have salutary and gentle remedial effect.
278. How small must it be? Theories and speculation are not the answer. Careful observation and accurate experience alone determines this.
279. Experience shows that a selected and highly potentized dose of the homeopathic remedy can never be too small to overpower a natural disease

280-to end: more on dosages and allied practices (mesmerism, baths, etc.)


280. Materialistic people don’t understand this. 
280: The dose should be gradually ascending as long as there is general improvement, followed by a mild return of old complaints. This indicates an approaching cure.

281: Everyone, especially in a diseased state, is capable of being influenced by the simillimum. Mere theoretical scepticism is ridiculous.
281. To be convinced, just give the patient placebo and watch him get better at this point

282. The dose can produce aggravation in the parts already affected. The artificial diseases substitutes for the natural disease.
282: if the dose is too large, the first dose produces an aggravation, especially in chronic diseases

283. The true healing artist prescribes his well selected remedy only in a minute dose. If it is the wrong medicine, the smallness of the dose will prevent injury
283: The true healing artist prescribes his well selected remedy only in a minute dose to avoid the homeopathic aggravation. If it is the wrong medicine, the smallness of the dose will prevent injury

284: The action of the dose does not diminish with quantity. Eight drops are not four times as strong as two drops
284: The nose and respiratory organs are receptive to the action of the medicines. The whole skin is also adapted to the action of medicinal solutions, especially when used with an internal remedy

285: The diminution of the dose is essential, as is the diminishing of the volume, i.e., a single globule
285: In very old diseases, the remedy may be rubbed on the back, arms, and extremities, while being given internally

286: The greater the quantity of fluid the dose is dissolved in, the better, since it comes into contact with more surface area
286: The dynamic forces of mineral magnets, electricity, and galvanism act upon the life principle. We don’t know enough about them to use them homeopathically. The positive, pure actions upon the body have not been tested.

287: By diluting it further the effect is changed. Each person must judge for himself how to diminish the dose to make them suitable for sensitive patients
287: The powers of the magnet for healing purposes is outlined in the Materia Medica Pura.

288. The actions of the medicines in liquid form are certainly spirit-like in power. (footnote describing the effectiveness of olfaction)
288: Mesmerism and animal magnetism are also priceless gifts

289: Every part of the body that possess the sense of touch is capable of receiving the medicines.
289: Discussion of positive and negative mesmerism

290: The interior of the nose, rectum, and genitals are also sensitive to the medicinal agents
290: Advantages of massage in the cases of a chronic invalid

291: Even organs which have lost their sense (i.e., sense of smell) will be susceptible to the remedy
291: Discussion of hydrotherapy.

292: Even the external parts of the body would be susceptible, especially if the remedy is in liquid form

293: A reference to Mesmer and the powers of “animal magnetism” and the curative effects of hypnosis

294: Continued discussion of “positive” and “negative” mesmerism, in light of the vital force

Cutaneous t-cell lymphoma.

NIH-cutaneous t-cell lymphoma-Non-Hodgkin’s lymphoma – Mycosis Fungoids

Mycosis fungoides was first described in 1806 by French dermatologist Jean-Louis-Marc Alibert. The name mycosis fungoides is very misleading—it loosely means “mushroom-like fungal disease”. The disease, however, is not a fungal infection but rather a type of non-Hodgkin’s lymphoma. It was so named because Alibert described the skin tumors of a severe case as having a mushroom-like appearance. ~Content Source